First-in-Human Study of the PARP Inhibitor HWH340 in Advanced Solid Tumors with Enrichment for Homologous Recombination ...
Introduction Poly(ADP-ribose) polymerases (PARPs) play a crucial role in DNA repair by catalyzing the transfer of ADP-ribose units from NAD+ to specific target proteins. Poly(ADP-ribose) polymerase inhibitors (PARPis) are a class of drugs that selectively …